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GSK963 (Racemate)

CAS No. 2049868-46-2

GSK963 (Racemate)( —— )

Catalog No. M20223 CAS No. 2049868-46-2

GSK963 (Racemate) a structurally distinct potent and selective inhibitor of RIP1 kinase(IC50=29?nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GSK963 (Racemate)
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK963 (Racemate) a structurally distinct potent and selective inhibitor of RIP1 kinase(IC50=29?nM).
  • Description
    GSK963 (Racemate) a structurally distinct potent and selective inhibitor of RIP1 kinase(IC50=29?nM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:C57BL/6 mice.Dosage:0.2 mg/kg, 2 mg/kg, 10?mg/kg.Administration:IP once.Result:Protected mice from TNF+zVAD-induced hypothermia.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    TNF
  • Recptor
    RIP1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2049868-46-2
  • Formula Weight
    230.31
  • Molecular Formula
    C14H18N2O?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:40 mg/mL (173.67 mM)
  • SMILES
    CC(C)(C)C(=O)N1N=CCC1c1ccccc1
  • Chemical Name
    22-Dimethyl-1-(5(S)-phenyl-45-dihydro-pyrazol-1-yl)-propan-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Berger SB et al. Characterization of GSK'963: a structurally distinct potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009.
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